Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 24, Pages 5486-5489Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00579g
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Funding
- National Institutes of Health [1R01AI085161-01]
- University of Oklahoma College of Arts and Sciences
- Department of Chemistry and Biochemistry
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI085161] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE018893] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM092219] Funding Source: NIH RePORTER
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The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress tolerance factors. We have now characterized the major compound generated from this gene cluster, mutanobactin A, and demonstrated that this secondary metabolite is also capable of influencing the yeast-mycelium transition of Candida albicans.
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