4.6 Article

Efficient synthesis of alkyl aryl ketones & ketals via palladium-catalyzed regioselective arylation of vinyl ethers

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 9, Pages 2012-2015

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c001004a

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Funding

  1. National Natural Science Foundation of China [20873179]
  2. Renmin University of China
  3. ESPRC

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The combination of Pd(OAc)(2) with 1,3-bis(diphenylphosphino)propane (dppp) in ethylene glycol constitutes a high-performance catalytic system for highly regioselective arylation of a range of electron-rich vinyl ethers by aryl bromides to provide, upon hydrolysis, alkyl aryl ketones and cyclic ketals in good yields with up to 3.75 x 10(5) TON and 15625 h(-1) TOF.

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