Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 6, Pages 1275-1279Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b925962g
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Funding
- Program for Academic Leader in Wuhan Municipality [200851430486]
- National Science Foundation of China [20672040, 20872043]
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A series of thiourea-amine bifunctional catalysts have been developed by a rational combination of prolines with cinchona alkaloids, which are connected by a thiourea motif. The catalyst 3a, prepared from L-proline and cinchonidine, was found to be a highly efficient catalyst for the conjugate addition of ketones/aldehydes to a wide range of nitroalkenes (up to 98/2 dr and 96% ee). The privileged cinchonidine backbone and the thiourea motif are essential to the reaction activity and enantioselectivity.
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