Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 22, Pages 5087-5096Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00119h
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- BBSRC
- Ministry of Higher Education (Egypt)
- BBSRC [BB/D005981/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D005981/1] Funding Source: researchfish
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3-Aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d] pyrimidin-2(7H)-one were synthesised and incorporated directly into triplex-forming oligonucleotides in order to utilise their extended hydrogen bonding motif for recognition of the CG base pair. All analogues demonstrated strong binding affinity and very good selectivity for CG from pH 6.2 to 7.0; a marked improvement on previous modifications.
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