Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 9, Pages 2252-2259Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c001307b
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Funding
- NIH [R01 CA127731, U54MH074425, U54MH084690]
- University of New Mexico Cancer Research and Treatment Center NIH [P30 CA118100]
- New Mexico Cowboys for Cancer Research Foundation
- Oxnard Foundation
- Stranahan Foundation
- NATIONAL CANCER INSTITUTE [P30CA118100, R01CA127731] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [U54MH084690, U54MH074425] Funding Source: NIH RePORTER
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The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(III)-catalyzed aza-Diels-Alder cyclization. Optimization of solvent and reaction temperature provided enhanced endo-diastereoselectivity.
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