4.6 Article

A novel pseudo four component reaction involving homoenolate for the synthesis of gamma-aminobutyric acid (GABA) derivatives

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 4, Pages 761-764

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b922981g

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Funding

  1. Department of Science and Technology (DST), New Delhi
  2. Council of Scientific and Industrial Research (CSIR), New Delhi

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Homoenolate generated from alpha,beta-unsaturated aldehydes by NHC catalysis underwent facile addition to conjugated sulfonimines, generated in situ, and subsequent methanolysis to afford protected GABA derivatives stereoselectively and in high yields, thus constituting a novel pseudo four component reaction.

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