4.6 Article

A thiophen-thiooxorhodamine conjugate fluorescent probe for detecting mercury in aqueous media and living cells

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 21, Pages 4819-4822

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00452a

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Funding

  1. State Key Laboratory of Materials-Oriented Chemical Engineering [KL09-9]
  2. Postgraduate practice innovation fund of Jiangsu province
  3. Nanjing University of Technology

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A rhodamine-based sensor RB-S2 was designed and synthesized by combination of the thiospirolacton chromophore and the thiophen ring block with high affinity to Hg2+. Probe RB-S2 exhibits high selectivity and excellent sensitivity in both absorbance and fluorescence detection of Hg2+ in aqueous solution. In addition, fluorescent imaging of Hg2+ in MCF-7 cells is also successfully demonstrated.

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