Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 22, Pages 5113-5119Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00363h
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Funding
- Medical Research Council [MC_U117584228] Funding Source: Medline
- MRC [MC_U117584228] Funding Source: UKRI
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Peptide thioesters are important tools for protein synthesis and semi-synthesis through their use in Native Chemical Ligation (NCL). NCL can be employed to assemble site-specifically modified proteins that can help elucidate the mechanisms of biomolecular processes. In this article we explore the compatibility of phosphopeptide synthesis and glycopeptide synthesis with thioester production through N -> S acyl transfer.
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