Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 10, Pages 2386-2391Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c000835d
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Funding
- National Basic Research Program of China [2010CB126101]
- Shanghai Foundation of Science of Technology [09391911800]
- National High Technology Research and Development Program of China [2006AA10A201]
- Shanghai Leading Academic Discipline Project [B507]
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We describe the development of a novel synthesis strategy that uses common reaction conditions to transform a collection of simple building blocks into complex molecules bearing a terminal difluoromethyl group. The core of this approach is the conscious design and synthesis of new difluorinated building blocks which contain inactive and reactive groups on each side of the CF(2) group. The strategy is illustrated by application to the synthesis of CF(2)H-bearing pseudopeptides via Ugi reaction.
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