4.6 Article

Multicomponent asymmetric reactions mediated by proline lithium salt

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 5, Pages 980-983

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b924158b

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Funding

  1. Universita Sapienza di Roma
  2. Royal Society of Chemistry Research Bursary

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The multicomponent reaction between proline lithium salt, 2-cyclohexen-1-one and aliphatic aldehydes affords the 4-alkylidene-2-cyclohexen-1-ones, which are interesting fragrances, and bicyclic amino acids that bear four additional stereocenters, obtained as single stereoisomer.

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