4.6 Article

Enantioselective construction of lactone[2,3-b]piperidine skeletons via organocatalytic tandem reactions

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 4, Pages 755-757

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b922053d

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Funding

  1. National Natural Science Foundation of China [20972101]
  2. PCSIRTC [IRT0846]
  3. National Basic Research Program of China (973 Program) [2010CB833303]

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A highly enantioselective construction of delta- and gamma-lactone[2,3-b] piperidine skeletons was accomplished by tandem aza-Diels-Alder reaction-hemiacetal formation-oxidation from N-Tos-1-aza-1,3-butadienes and aliphatic dialdehydes.

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