4.6 Article

Enantioselective desymmetrizing palladium catalyzed carbonylation reactions: the catalytic asymmetric synthesis of quaternary carbon center containing 1,3-dienes

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 4, Pages 758-760

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b923186b

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Funding

  1. EPSRC
  2. F. Hoffmann-La Roche Ltd
  3. Engineering and Physical Sciences Research Council [EP/C011074/2] Funding Source: researchfish

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A desymmetrization protocol has been used to develop a palladium catalyzed enantioselective carbonylation process. Achiral cyclic bis-alkenyltriflates are converted to their corresponding monoester derivatives with selectivities of up to 96% ee.

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