Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 8, Pages 1749-1762Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b923331h
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Funding
- Ministry of Education [R143-000-394-112]
- Agency for Science, Technology and Research (A*Star) of Singapore [R143-000-391-305]
- National Research Foundation [R143-000-218-281]
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Of the thousands of known chemical reactions, a handful of reactions, called click reactions, stand out with features such as good chemoselectivity, good solvent compatibilities, modularity, minimum synthetic demands, bioorthogonality and high yields. Among them, the Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction between azides and terminal alkynes has emerged as a powerful tool in chemical biology and proteomics. This perspective surveys the significant contributions of click chemistry in catalomics (a sub-area in chemical proteomics), with special emphasis on activity-based protein profiling (ABPP), posttranslational modifications (PTMs) and enzyme inhibitor developments.
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