Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 7, Pages 1712-1717Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b917217c
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- Natural Sciences and Engineering Research Council of Canada
- American Chemical Society Petroleum
- Ontario Government for a Science and Technology
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An increasing number of reactions of sulfenic acid anions are being demonstrated in the literature. As such, mild, general and reliable means for the generation of sulfenates are due. In the current paper, an addition/elimination of 2-sulfinyl acrylates using various nucleophiles is demonstrated and evaluated as a protocol for alkane-and arenesulfenate generation. Cyclohexanethiolate, methoxide and n-butyllithum each exhibit some merit for the reaction, and the thiolate is established as a mild, selective and effective reagent to release sulfenates from 2-sulfinyl acrylates. The stereospecificity of the addition/elimination of each nucleophile is recognized, and an explanation for the specificity is offered for thiolate and methoxide.
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