4.6 Article

A click chemistry approach to C-3 symmetric, G-quadruplex stabilising ligands

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 13, Pages 2926-2930

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c005055e

Keywords

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Funding

  1. EPSRC
  2. Association for International Cancer Research (AICR)
  3. University of Nottingham
  4. CRUK
  5. Cancer Research UK
  6. Engineering and Physical Sciences Research Council [EP/E059643/1] Funding Source: researchfish
  7. EPSRC [EP/E059643/1] Funding Source: UKRI

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Described is the structure-based design and synthesis of a series of tris-triazole G-quadruplex binding ligands utilising the copper catalysed azide-alkyne 'click' reaction. The results of G-quadruplex stabilisation by the ligands are reported and discussed.

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