Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 9, Pages 2043-2051Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b920946h
Keywords
-
Categories
Funding
- CNPq
- CAPES
- FAPESP
- Province of Stryria
- Codexis
- FFG
Ask authors/readers for more resources
omega-Transaminases have been evaluated as biocatalysts in the reductive amination of organoselenium acetophenones to the corresponding amines, and in the kinetic resolution of racemic organoselenium amines. Kinetic resolution proved to be more efficient than the asymmetric reductive amination. By using these methodologies we were able to obtain both amine enantiomers in high enantiomeric excess (up to 99%). Derivatives of the obtained optically pure o-selenium 1-phenylethyl amine were evaluated as ligands in the palladium-catalyzed asymmetric alkylation, giving the alkylated product in up to 99% ee.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available