Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 1, Pages 137-141Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b916601g
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Funding
- EPSRC [GR/S87294/01, EP/E018211/1]
- Royal Society of Edinburgh
- Astra Zeneca
- University of Glasgow
- TUBITAK [105S353]
- TUBA-GEBIP
- Engineering and Physical Sciences Research Council [EP/E018211/1, GR/S87294/01] Funding Source: researchfish
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Asymmetric reduction of ketimines 1a-f with trichlorosilane can be catalysed by the Lewis-basic N-methylvaline-derived formamide anchored to a soluble dendron (11c) with good enantioselectivity (<= 94% ee) and low catalyst loading (typically 5 mol%) at room temperature in toluene. This protocol represents an improvement and simplification of the isolation procedure and recovery of the catalyst.
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