4.6 Article

Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 1, Pages 39-42

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b919673k

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan

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A catalytic amount of TEMPO in the presence of PhI(OAc)(2) effected oxidative lactonization of 1,6- and 1,7-diols, directly affording seven- and eight-membered lactones, respectively, in good yields.

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