4.6 Article

Studies on highly regio- and stereoselective hydration of 1,2-allenylic sulfoxides

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 20, Pages 4554-4561

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00007h

Keywords

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Funding

  1. National Natural Science Foundation of China [20572093]
  2. State Basic Research and Development Porgram of China [2009CB825300]

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A highly regio- and stereoselective hydration of 1,2-allenylic sulfoxides in which proton served as the electrophile was reported. Through the X-ray diffraction study, it was concluded that the reaction may proceed via a 5-membered cyclic intermediate following by attack of the -OH at the sulfur atom.

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