Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 8, Pages 1777-1780Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b926316k
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Funding
- La Region Haute-Normandie
- QUIDD
- Institut Universitaire de France (IUF)
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This study focuses on the disassembly-behavior of self-immolative pro-fluorescent linkers under physiological conditions and through an enzyme-initiated domino reaction. The targeted linkers are based on para-aminobenzylalcohol (PABA) or hemithioaminal derivatives of para-carboxybenzaldehyde or glyoxilic acid. We found that a fine tuning of the kinetic properties could be obtained through the modulation of the linker structure, giving either a fast signal response or free-adaptable systems suitable for the design of protease-sensitive fluorogenic probes or prodrug systems.
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