4.6 Article

Palladium-catalyzed decarboxylative cross-coupling reaction of cinnamic acid with aryl iodide

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 7, Issue 5, Pages 863-865

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b821870f

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Funding

  1. National Natural Science Foundation of China [20772018]
  2. Shanghai Pujiang Program
  3. Program for New Century Excellent Talents in University [NCET-07-0208]

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A highly effective decarboxylative cross-coupling reaction of cinnamic acid with aryl iodide catalyzed by the combination of palladium chloride and CyJohnPhos in the presence of Ag2CO3 as an additive is described. The desired carbon-carbon bond formation proceeds efficiently with good functional-group tolerance.

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