4.6 Article

A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 7, Issue 3, Pages 435-438

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b819208a

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Funding

  1. University of Oklahoma College of Arts and Sciences
  2. Department of Chemistry and Biochemistry
  3. UROP

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A new fungal metabolite, nygerone A (1), featuring a unique 1-phenylpyridin-4(1H)-one core that had previously not been reported from any natural source, has been obtained from Aspergillus niger using a chemical epigenetics methodology.

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