4.6 Article

Asymmetric esterification of ketenes catalyzed by an N-heterocyclic carbene

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 7, Issue 2, Pages 346-350

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b815139c

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Funding

  1. Chinese Academy of Sciences
  2. Natural Sciences Foundation of China [20602036]

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The chiral N-heterocyclic carbene precursor 2, derived from L-pyroglutamic acid, was found to be an efficient precatalyst for the enantioselective esterification of alkylarylketenes with benzhydrol to give the corresponding esters in good yields with good to high enantioselectivities (up to 95% ee).

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