Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 7, Issue 20, Pages 4271-4278Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b912033e
Keywords
-
Categories
Funding
- CNRS
Ask authors/readers for more resources
An efficient site selective method for the direct arylation of free-(NH2) adenines 1 to provide a range of C-8 arylated adenines 3 in excellent yields is described. This process based on the use of Pd(OH)(2)/C as the catalyst and a stoichiometric amount of CuI under ligandless conditions is general. It allows the coupling to proceed with a variety of aryl halides, including for the first time cheaper and less reactive aryl chlorides. The extension of this process for the sequential preparation of non-symmetrical C8/N-6-arylated adenines 4 is also reported.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available