Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 7, Issue 17, Pages 3430-3436Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b908713c
Keywords
-
Categories
Funding
- NIH [U24-CA092782, U01-HL080731, U54-CA119349, U54-CA126515]
- NATIONAL CANCER INSTITUTE [U54CA119349, U54CA126515, U24CA092782] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U01HL080731] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Next-generation photodynamic therapy agents based upon the conjugation of multiple photosensitizers to a targeting backbone will allow for more efficacious light-based therapies. To this end, we have developed glucose-modified chlorins and bacteriochlorins featuring a reactive carboxylic acid linker for conjugation to targeting moieties. The photosensitizers were synthesized in relatively high yields from meso-tetra(p-aminophenyl) porphyrin, and resulted in neutral, hydrophilic chromophores with superb absorption profiles in the far-red and near-infrared portions of the electromagnetic spectrum. In addition, conjugation of these photosensitizers to a model nanoscaffold (crosslinked dextran-coated nanoparticles) demonstrated that the inclusion of hydrophilic sugar moieties increased the number of dyes that can be loaded while maintaining suspension stability. The described compounds are expected to be particularly useful in the synthesis of a number of targeted nanotherapeutic systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available