Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 7, Issue 22, Pages 4641-4646Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b914265g
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Funding
- National Natural Science Foundation of China [20772018]
- Science and Technology Commission of Shanghai Municipality [09JC14049]
- Program for New Century Excellent Talents in University [NCET-07-0208]
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Diversity-oriented synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N'-(2-alkynylbenzylidene)hydrazide is described. Bromine-mediated electrophilic cyclization, Ag-catalyzed alkyne nucleophilic addition, and palladium-catalyzed cross-coupling reaction were involved in the transformation.
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