Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 7, Issue 19, Pages 4037-4044Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b910015f
Keywords
-
Categories
Funding
- MIUR (PRIN 2007) Sostanze Naturali ed Analoghi Sintetici con Attivita Antitumorale Rome, Italy
Ask authors/readers for more resources
Nine new cyclodepsipeptides, homophymines B-E (2-5) and A1-E1 (1a-5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC50 in the nM range) against a panel of human cancer cell lines.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available