4.6 Article

Asymmetric reduction of ketimines with trichlorosilane employing an imidazole derived organocatalyst

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 7, Issue 2, Pages 229-231

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b816051a

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Funding

  1. Aesica Pharmaceuticals Ltd.
  2. The University of Sheffield

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Organocatalysts for the asymmetric reduction of ketimines are presented that function well at low catalyst loadings providing chiral amines in good yield and enantioselectivity, the latter appearing to be independent of the ketimine substrate geometry.

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