Facile preparation of CF3-substituted carbinols with an azine donor and subsequent kinetic resolution through stereoselective Si-O coupling

A number of CF3-substituted carbinols decorated with an azine donor are efficiently prepared from fluoral and kinetically resolved in a reagent-controlled, Cu-H-catalysed Si-O coupling with a chiral silane. Selectivity factors are high, indicating a larger steric effect than CH3 or C6H5 groups.