Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 7, Issue 19, Pages 4029-4036Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b909729e
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Funding
- Wellcome Trust [067525/Z/02/Z, VS/07/QUEB/A5]
- the Department of Employment and Learning (ASR)
- the National Institutes of Health [GM-35394]
- the Southeast Regional Centre of Excellence for Biodefense and Emerging Infections
- Engineering and Physical Sciences Research Council (EPSRC) Mass Spectrometry Service Centre, Swansea
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM035394] Funding Source: NIH RePORTER
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The synthesis of a library of nucleoside triphoshate mimetics is described where the Mg2+ chelated triphosphate sidechain is replaced by an uncharged methylene-triazole linked monosaccharide sidechain. The compounds have been evaluated as inhibitors of Bacillus anthracis pantothenate kinase and a competitive inhibitor has been identified with a K-i that is 3-fold lower than the K-m value of ATP.
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