Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 7, Issue 4, Pages 660-664Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b815956d
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Funding
- NNSF of China [20673132]
- Croucher Foundation of Hong Kong
- Chinese Academy of Sciences hundred talents program
- National Basic Research Program of China [2006CB933000]
- 111 Project [B07012]
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Thiorhodamine-based chemodosimeter A, a disulfide linked dimer, was designed for Hg2+ recognition by virtue of the strong affinity of mercury for sulfur. Spectroscopic results reveal that chemodosimeter A exhibits real-time responses, and high sensitivity and selectivity for Hg2+ in comparison to other cations. These properties are mechanistically ascribed to the transfer from rhodamine spirolactam to the thiazoline-derived open-ring rhodamine via Hg2+ induced desulfurization. The in vitro recognition of Hg2+ in living cells pretreated with A was examined, showing that the concentration of Hg2+ that could be imaged reaches the safety limit for human beings.
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