4.6 Article

Epigenetic remodeling of the fungal secondary metabolome

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 6, Issue 11, Pages 1895-1897

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b804701d

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Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.

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