4.6 Article

Mechanistic approaches to palladium-catalyzed alkene difunctionalization reactions

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 6, Issue 22, Pages 4083-4088

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b813246a

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Funding

  1. NIGMS NIH HHS [R01 GM063540, R01 GM063540-06A2] Funding Source: Medline
  2. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM063540] Funding Source: NIH RePORTER

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Alkene difunctionalization, the addition of two functional groups across a double bond, exemplifies a class of reactions with significant synthetic potential. This emerging area examines recent developments of palladium-catalyzed difunctionalization reactions, with a focus on mechanistic strategies that allow for functionalization of a common palladium alkyl intermediate.

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