4.6 Article

N-Heterocyclic carbene catalysed beta-lactam synthesis

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 6, Issue 6, Pages 1108-1113

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b800857b

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N-Heterocyclic carbenes promote the formal [2+2] cycloaddition of ketenes with N-tosyl imines to give the corresponding beta-lactams in good to excellent isolated yields; chiral NHCs give beta-lactams in high e. e. after crystallisation.

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