4.6 Article

Synthesis of 8-bromo-, 8-methyl- and 8-phenyl-dATP and their polymerase incorporation into DNA

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 6, Issue 20, Pages 3657-3660

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b811935j

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Funding

  1. Ministry of Education [LC512]
  2. Gilead Sciences, Inc. (Foster City, CA, U. S. A.)

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dATP derivatives bearing Br, Me or Ph groups in position 8 were prepared and tested as substrates for DNA polymerases to show that 8-Br-dATP and 8-Me-dATP were efficiently incorporated, while 8-Ph-dATP was a poor substrate due to its bulky Ph group.

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