Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 6, Issue 23, Pages 4460-4466Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b808804g
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C-(2-Benzyloxy)-ethyl-C'-N-tert-butoxycarbonyl-aminomethyl-o-carborane (8), a potentially useful intermediate for BNCT, has been synthesised. This intermediate can be readily functionalised with several biological vectors and MRI contrast agents. In this work intermediate 8 has been functionalised with a palmityl chain for lipophilic targeting and with Gd(III)-DOTAMA-C-6-NH2 as MRI detector. This combination yielded Gd(III)-C-palmitamidomethyl-C'-DOTAMA-C-6-o-carborane (14) as a dual MRI-BNCT agent.
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