Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 6, Issue 21, Pages 3888-3891Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b813584c
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Funding
- EPSRC
- EPSRC [EP/E045693/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/E045693/1] Funding Source: researchfish
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A diphenyl porphyrin substituted nucleotide was incorporated site specifically into DNA, leading to helical stacked porphyrin arrays in the major groove of the duplexes. The porphyrins show an electronic interaction which is significantly enhanced compared to the analogous tetraphenyl porphyrin (TPP) as shown in the large exciton coupling of the porphyrin B-band absorbance. Analogous to the TPP DNA, an induced helical secondary structure is observed in the single strand porphyrin-DNA. The modified DNA can be hybridised to an immobilised complementary strand leading to fluorescent beads.
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