Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 6, Issue 19, Pages 3464-3466Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b807575a
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A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation-substitution sequence; an efficient synthesis of (+)-myrtine has been achieved via this route.
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