Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 6, Issue 15, Pages 2706-2712Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b803608j
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2,3-Diaryl-5-ethylsulfanylmethyltetrahydrofuran-3-ols were designed and synthesized by the allylations of benzoins followed by iodocyclization and nucleophilic replacement reactions with ethanthiol. These molecules exhibit IC50 for COX-2 at < 10 nM concentration and exhibit average GI(50) over all the 59 human tumor cell lines at mu M concentration.
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