4.6 Article

A highly fluorescent nucleoside analog based on thieno[3,4-d] pyrimidine senses mismatched pairing

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 6, Issue 8, Pages 1334-1338

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b801054d

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Funding

  1. NIGMS NIH HHS [GM 069773, R01 GM069773] Funding Source: Medline
  2. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM069773] Funding Source: NIH RePORTER

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A highly emissive nucleobase analog, based on a thieno[3,4-d] pyrimidine core, is enzymatically incorporated into RNA oilgonucleotides that function as base discriminating fluorescent probes.

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