Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 6, Issue 7, Pages 1244-1250Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b718352f
Keywords
-
Categories
Ask authors/readers for more resources
A compound library of 96 enantiopure N-terminal succinyl hydroxamate functionalized peptides was synthesized on solid phase. All compounds were tested for their inhibitory potential towards MMP-9, MMP-12 and ADAM-17, which led to the identification of both broad spectrum inhibitors and metalloproteinase-selective ones. Eight potent and less potent inhibitors were immobilized on Sepharose beads and evaluated in solid-phase enrichment of active MMP-9, MMP-12 and ADAM-17. In addition, one of these inhibitors was used for solid-phase enrichment of endogenous ADAM-17 from a complex proteome ( a lysate prepared from cultured A549 cells).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available