Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 6, Issue 23, Pages 4348-4355Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b811086g
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Funding
- National Research Foundation of South Africa [FA2005040600033]
- Stellenbosch University
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N-Substituted pantothenamides are a class of pantothenic acid analogues which have been shown to act as inhibitors of coenzyme A biosynthesis and utilization, especially by blocking fatty acid metabolism through formation of inactive acyl carrier proteins. To fully explore the chemical diversity and inhibitory potential of these analogues we have developed a simple method for the parallel synthesis and purification of any number of pantothenamides from a single precursor, and subsequently evaluated a small library of these compounds as inhibitors of bacterial growth to demonstrate the potential and utility of the method.
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