4.6 Article

A modular approach to catalyst hydrophobicity for an asymmetric aldol reaction in a biphasic aqueous environment

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 6, Issue 22, Pages 4224-4229

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b812607k

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Catalyst 5, an ion pair consisting of a hydrophilic cation and a lipophilic anion, fulfils the solubility requirements needed to couple efficiency (enantioselectivities and anti-diastereoselectivities up to >= 99%) and catalyst recyclability in asymmetric aldol reactions under aqueous biphasic conditions.

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