Journal
ORAL ONCOLOGY
Volume 50, Issue 3, Pages 234-239Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.oraloncology.2013.12.003
Keywords
Human papillomavirus; Chemoradiotherapy; PET/CT; Metabolic response; PET surveillance
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Funding
- NCI NIH HHS [P50 CA097248, P30 CA046592] Funding Source: Medline
- NIDCR NIH HHS [R01 DE019126] Funding Source: Medline
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Objectives: Although widely adopted, the accuracy of post-chemoradiotherapy (CRT) F-18-fluorodeoxygluocose positron emission tomography/computed tomography (PET/CT) for predicting locoregional failure (LRF) in human papillomavirus-related (HPV+) oropharyngeal cancer (OPC) remains poorly characterized. We assessed the predictive value of 3-month PET/CT response for LRF in this population. Materials and methods: 101 consecutive patients with stage III-IV HPV+ OPC who underwent definitive CRT with pre-treatment and 3-month post-CRT PET/CT at our institution from 3/2005-3/2011 were included. 3-month PET/CT response was re-classified as complete-response (CR), near-CR, or incomplete- response (
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