Journal
ORAL ONCOLOGY
Volume 50, Issue 10, Pages 963-970Publisher
ELSEVIER
DOI: 10.1016/j.oraloncology.2014.07.011
Keywords
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI); Head and neck cancer; Biomarker; Perfusion imaging; Hypoxia
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Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamous cell carcinoma (HNSCC). A systematic review was conducted of prospective DCE-MRI parameter studies in HNSCC in the English language literature. Exclusion criteria were case reports and retrospective series. Six DCE-MRI marker studies in HNSCC met the inclusion criteria. Four studies contained 21-74 patients and two studies recruited 13 and 14 patients. In studies measuring the transfer coefficient (K-trans), higher overall K-trans or lower skewness of K-trans were predictive of a good outcome following chemoradiation. DCE-MRI parameters have the potential to guide treatment in HNSCC. Progress in the field requires standardisation of methods, data sharing and large multi-centre collaborative validation studies. (C) 2014 Elsevier Ltd. All rights reserved.
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