Journal
ORAL ONCOLOGY
Volume 49, Issue 8, Pages 726-732Publisher
ELSEVIER
DOI: 10.1016/j.oraloncology.2013.04.006
Keywords
Sentinel lymph node biopsy; Oral cavity; Oropharynx; Squamous cell cancer; Meta analysis
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Background: The aim of the study was to systematically assess the accuracy of a sentinel lymph node biopsy (SLNB) in cT1/T2N0 oral cavity and oropharyngeal squamous cell carcinoma patients. Methods: We searched electronic databases, including EMBASE and MEDLINE (Pubmed) up to November 7 2012, by combining oral cancer keywords with sentinel node biopsy keywords. We included diagnostic accuracy studies which used neck dissection as a reference test for the sentinel node biopsy. Study characteristics and measures of accuracy were extracted. Diagnostic accuracy was calculated from 2 x 2 tables. Results: 21 Studies (847 patients) could be included. Most of these patients had oral cavity squamous cell carcinoma (OCSCC). The pooled data showed an overall sensitivity of 0.93 [95% CI 0.90-0.95]. Subgroup analysis showed no significant differences in subgroups. Conclusion: The high sensitivity of SLNB supports a role in the diagnostic work-up of OCSCC. (C) 2013 Elsevier Ltd. All rights reserved.
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