Journal
ORAL ONCOLOGY
Volume 48, Issue 11, Pages 1068-1075Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.oraloncology.2012.06.005
Keywords
Epithelial-mesenchymal transition (EMT); Cancer stem cells (CSCs); Inflammation microenvironment
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Funding
- National Natural Science Foundation of China [81072215, 81001210, 81172580]
- Fundamental Research Funds of the Central Universities of China
- State Key Laboratory of Oral Diseases Open Funding [SKLO-DOF2010-05]
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Similar to actors changing costumes during a performance, cancer cells undergo many rapid changes during the process of tumor metastasis, including epithelial-mesenchymal transition (EMT), acquisition of cancer stem cells (CSCs) properties, and mesenchymal-epithelial transition (MET). Such changes allow the tumor to compete with the normal microenvironment to overcome anti-tumorigenic pressures. Then, once tissue homeostasis is lost, the altered microenvironment, like that accompanying inflammation, can itself become a potent tumor promoter. This review will discuss the changes that cancer cells undergo in converting from EMT to CSCs in an inflammation microenvironment, to understand the mechanisms behind invasion and metastasis and provide insights into prevention of metastasis. (C) 2012 Elsevier Ltd. All rights reserved.
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