Journal
ORAL ONCOLOGY
Volume 47, Issue 7, Pages 609-614Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.oraloncology.2011.05.006
Keywords
Trx; TrxR; Tongue cancer; Prognosis
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Funding
- National Natural Science Foundation of China [81070823]
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The human thioredoxin (Trx) system plays a critical role in the regulation of cellular reduction-oxidation (redox) homeostasis, which has been widely investigated in several types of cancer because of its association with cell growth and anti-apoptosis progress. This study aimed to evaluate the expression of Trx and Trx reductase-1 (TrxR-1) and explore the potential role of these proteins in tongue squamous cell carcinoma (TSCC). Immunohistochemistry was employed to analyze the protein expression levels of Trx and TrxR-1 in 65 TSCC tissue samples and 10 normal oral mucosa samples. The results were then evaluated semiquantitatively and compared to other clinicopathological variables. Both Trx and TrxR-1 expression levels were significantly higher in TSCC tissues as compared with the 10 normal oral mucous samples (P < 0.01). A highly significant association between Trx and TrxR-1 expression in TSCCs was revealed (P = 0.001), and the expression of Trx was correlated with tumour cell differentiation (P = 0.001). Moreover, Kaplan-Meier analysis revealed that Trx expression and TNM stage were significantly related with 5-year survival rate (P = 0.033, 0.000), while TrxR-1 expression was not associated with survival (P = 0.092). The results indicated that high expression of Trx and TrxR-1 was associated with tumourigenesis in TSCC, and overexpression of Trx might predict poor prognosis. (C) 2011 Elsevier Ltd. All rights reserved.
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