Journal
ORAL ONCOLOGY
Volume 46, Issue 3, Pages 204-208Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.oraloncology.2009.12.005
Keywords
Carcinoma; MicroRNA; Oral cavity; Plasma; Proliferation; miR-24
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Funding
- National Science Council, Taiwan [96-2628-B-010-033-MY3]
- Chi-Yang Grant [CMYM9802]
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MicroRNAs (miRNAs) play important roles in neoplastic process. miR-24 is localized on chromosome 9q22 and 19p13, regions frequently altered in oral squamous cell carcinoma (OSCC). This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSCC patients were significantly higher than in control individuals. miR-24 expression was also higher in OSCC cell lines relative to normal oral keratinocytes. Experiments blocking miR-24 and using exogenous miR-24 expression indicated that miR-24 contributes to the growth of OSCC cells and that miR-24 may target p57. This study suggests that miR-24 is involved in the regulation of OSCC growth and that the miR-24's level in plasma may be validatable as a tumor marker for OSCC patients. (C) 2010 Elsevier Ltd. All rights reserved.
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