Journal
ORAL ONCOLOGY
Volume 45, Issue 1, Pages 2-9Publisher
ELSEVIER
DOI: 10.1016/j.oraloncology.2008.03.012
Keywords
Mucoepidermoid carcinoma; Warthins tumour; Salivary gland tumours; Translocation; t(11;19); MAML2; CRTC1; Oncogene; Prognosis; Review
Categories
Ask authors/readers for more resources
Mucoepidermoid carcinoma (MEC) is a relatively uncommon carcinoma of variable histology that can involve many tissue types, most commonly major and minor salivary glands and the tracheo-bronchial. tree. In a significant number of cases a recurring t(11;19) translocation with an associated novel fusion oncogene (CRTC1-MAML2) is present. This translocation is also found in Warthin's tumour and clear cell hidradenoma of the skin. The CRTC1-MAML2 oncogene acts as a transcription factor on Notch and CREB regulatory pathways, disrupting cell-cycle and differentiation, contributing to tumour development. Data suggest that in MEC, the presence of CRTC1-MAML2 may have some prognostic value. An understanding of mechanisms extends our knowledge of the rote of fusion oncogenes in epithelial malignancy. A review of CRTC1-MAML2 in MEC is presented. (C) 2008 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available